BDBM160931 US20240208984, Compound VZMC001::US9107954, 1

SMILES CC(C)c1nnc(C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4CC2CC2)c56)cc1

InChI Key

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 160931   

TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataIC50: 40nMAssay Description:As Ca2+ flux is associated with the activation of the MOR, the functional activity of bivalent ligand 1, monovalent ligand 2, and naltrexone was then...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
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TargetC-C chemokine receptor type 5(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataIC50: 126nMAssay Description:Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
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TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mu opioid receptor expressed in Gqi5 transfected CHO cells assessed as inhibition of DAMGO-stimulated Ca2+ influx preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataKi:  51.8nMAssay Description:A bivalent ligand 1 (FIG. 14) that combines the pharmacophores of naltrexone (a MOR antagonist) and maraviroc (a CCR5 antagonist) into one molecule w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
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TargetProtein MOR1(Mouse-ear cress)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataKi:  51.8nMAssay Description:The competition binding assay was conducted using monoclonal mouse MOR expressed in Chinese hamster ovary (CHO) cell lines. In this assay, 30 μg...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]-naloxone from human mu opioid receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataKi:  239nMAssay Description:Afterwards, the pharmacological profile of bivalent ligand 1 at the chemokine receptor CCR5 was characterized similarly. The competitive radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
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TargetC-C chemokine receptor type 5(Crab-eating macaque)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataKi:  239nMAssay Description:Displacement of [125I]-MIP-1alpha from CCR5 in rhesus monkey Chem-1 cell membranes after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Virginia Commonwealth University

US Patent
LigandPNGBDBM160931(US9107954, 1 | US20240208984, Compound VZMC001)
Affinity DataKi:  239nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent