BDBM159843 BDBM159925::US9040528, 2::US9040528, 2(b)

SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(C)noc4c(F)c23)C(=O)NC(=O)NC1=O

InChI Key InChIKey=FWKBFPFKHVTISW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 159843   

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(US9040528, 2 | US9040528, 2(b) | BDBM159925)
Affinity DataIC50: 400nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/ml of topologic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(US9040528, 2 | US9040528, 2(b) | BDBM159925)
Affinity DataIC50: 300nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/ml of topologic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(US9040528, 2 | US9040528, 2(b) | BDBM159925)
Affinity DataIC50: 300nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/ml of topologic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetDNA topoisomerase 2-alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM159843(US9040528, 2 | US9040528, 2(b) | BDBM159925)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human topoisomerase 2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(US9040528, 2 | US9040528, 2(b) | BDBM159925)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMed