BDBM15926 Aminopyridine-Based Inhibitor 6e::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-phenylacetamide

SMILES CCOc1nc(NC(=O)Cc2ccccc2)cc(N)c1C#N

InChI Key InChIKey=MPULMLDKNWNYOT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15926   

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15926(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-phenyla...)
Affinity DataIC50: 570nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Abbott Laboratories

LigandPNGBDBM15926(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-phenyla...)
Affinity DataIC50: 770nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2007
Entry Details Article
PubMed
Target40S ribosomal protein S27(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM15926(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-phenyla...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of Mps1-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15926(N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-phenyla...)
Affinity DataIC50: 260nMAssay Description:Inhibition of JNK1-mediated ATF2 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed