BDBM159199 US10195186, Example 40::US9682967, 38

SMILES OC(=O)c1cc(ccc1C(=O)NCc1ccccn1)C(F)(F)F

InChI Key InChIKey=MXGLAJZUFCFEBH-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 159199   

TargetSortilin(Human)
H. Lundbeck

US Patent
LigandPNGBDBM159199(US9682967, 38 | US10195186, Example 40)
Affinity DataIC50: 4.80E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSortilin(Human)
H. Lundbeck

US Patent
LigandPNGBDBM159199(US9682967, 38 | US10195186, Example 40)
Affinity DataKi:  1.52E+3nM IC50: 1.60E+3nMpH: 7.4Assay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetSortilin(Human)
H. Lundbeck

US Patent
LigandPNGBDBM159199(US9682967, 38 | US10195186, Example 40)
Affinity DataKi:  4.57E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent