BDBM159182 US9034866, 659

SMILES Cc1cnc(o1)[C@@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O

InChI Key InChIKey=RODIOQSCTKCZKO-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 159182   

LigandPNGBDBM159182(US9034866, 659)
Affinity DataKi:  0.290nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase D1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM159182(US9034866, 659)
Affinity DataKi:  4.20nMAssay Description:Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM159182(US9034866, 659)
Affinity DataKi: >1.25E+3nMAssay Description:Inhibition of NIK (unknown origin) using ATP as substrate by transcreener ADP assay based fluorescence correlation spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM159182(US9034866, 659)
Affinity DataKi:  1.60E+3nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
Go to US Patent