BDBM15913 2-pyridinecarboxamide deriv. 8c::4-Amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide::4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphenyl)methyl]pyridine-2-carboxamide::CHEMBL424872

SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=CUIDQTVRAWOMCM-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 15913   

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataIC50: 19nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Abbott Laboratories

LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataIC50: 120nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2007
Entry Details Article
PubMed
TargetTranscription factor Jun(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataEC50:  318nMAssay Description:Inhibition of c-Jun phosphorylation in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Abbott Laboratories

LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataIC50: 120nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataIC50: 19nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target40S ribosomal protein S27(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataIC50: 568nMAssay Description:Inhibition of Mps1-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15913(4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphen...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1-mediated ATF2 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed