BDBM158654 US9034866, 129

SMILES Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(cn3C3CC(C3)c2cc1F)C(N)=O

InChI Key InChIKey=OHSPVJFJVRIKGA-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 158654   

LigandPNGBDBM158654(US9034866, 129)
Affinity DataIC50: 199nMAssay Description:Inhibition of NIK in human HeLa cells assessed as decrease in antilymphotoxin-beta receptor antibody-stimulated p52 translocation from cytoplasm to n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
LigandPNGBDBM158654(US9034866, 129)
Affinity DataIC50: 102nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells assessed as decrease in NFkappaB signal after 24 hrs by dual glo luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM158654(US9034866, 129)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated RELA translocation from cytoplasm to nucleus in human HeLa cells preincubated for 4.5 hrs followed by TNF-alpha st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
LigandPNGBDBM158654(US9034866, 129)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NIK (unknown origin) after 1 to 2 hrs by ADP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
LigandPNGBDBM158654(US9034866, 129)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM158654(US9034866, 129)
Affinity DataKi:  1nMAssay Description:Inhibition of NIK (unknown origin) using ATP as substrate by transcreener ADP assay based fluorescence correlation spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM158654(US9034866, 129)
Affinity DataKi:  3nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
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TargetSerine/threonine-protein kinase D1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM158654(US9034866, 129)
Affinity DataKi:  5.90nMAssay Description:Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM158654(US9034866, 129)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed