BDBM158485 US10383835, Compound 2228::US9029401, 2227

SMILES CNC(=O)c1ccc(O[C@H]2CCC(CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=JNPWHXLRBKEIPP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 158485   

TargetBifunctional epoxide hydrolase 2(Human)
University of California

US Patent
LigandPNGBDBM158485(US9029401, 2227 | US10383835, Compound 2228)
Affinity DataIC50: 0.5nMAssay Description:See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2015
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of California

US Patent
LigandPNGBDBM158485(US9029401, 2227 | US10383835, Compound 2228)
Affinity DataIC50: 340nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2015
Entry Details
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TargetSerine/threonine-protein kinase B-raf [V600E](Human)
University of California

US Patent
LigandPNGBDBM158485(US9029401, 2227 | US10383835, Compound 2228)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2015
Entry Details
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TargetEpoxide hydrolase(Horse)
University of California

US Patent
LigandPNGBDBM158485(US9029401, 2227 | US10383835, Compound 2228)
Affinity DataIC50: 1nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetEpoxide hydrolase(Sheep)
University of California

US Patent
LigandPNGBDBM158485(US9029401, 2227 | US10383835, Compound 2228)
Affinity DataIC50: 1nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetEpoxide hydrolase 1(Cat)
University of California

US Patent
LigandPNGBDBM158485(US9029401, 2227 | US10383835, Compound 2228)
Affinity DataIC50: 2nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent