BDBM158481 US9029401, 1728 (t-TUCB)

SMILES c1cc(ccc1C(=O)O)OC2CCC(CC2)NC(=O)Nc3ccc(cc3)OC(F)(F)F

InChI Key InChIKey=XDVFKCZZXOGEMN-UHFFFAOYSA-N

Data  1 KI  22 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 158481   

TargetFatty-acid amide hydrolase 1(Mouse)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of FAAH in mouse brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate assessed as 6-methoxynaphthaldehyde product formation preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant mouse soluble epoxide hydrolase using PHOME as substrate assessed as 6-methoxynaphthaldehyde product formation preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as fluorescent substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1nMAssay Description:Inhibition of human soluble epoxide hydrolase using CMNPC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Rat)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 54nMAssay Description:Inhibition of soluble epoxide in rat brain microsomes using CMNPC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 2(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON2 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human carboxylesterase 2 expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human carboxylesterase 1 expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAAH in rat brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 0.900nMAssay Description:See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetArylacetamide deacetylase(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AADAC (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/lactonase 3(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON3 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 140nMAssay Description:Inhibition of human FAAH expressed in baculovirus-infected High Five cells S9 fraction using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 0.400nMAssay Description:Inhibition of soluble epoxide hydrolase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpoxide hydrolase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of microsomal epoxide hydrolase (unknown origin) expressed in baculovirus system using CMNMC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 5.70nMAssay Description:Inhibition of soluble epoxide in mouse brain microsomes using CMNPC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 260nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of California

US Patent
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2015
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM158481(US9029401, 1728 (t-TUCB))
Affinity DataKi:  156nMAssay Description:Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using varying CMN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)