BDBM15791 3-N-[(2S,3S)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(1S)-1-[(2-methylpropyl)carbamoyl]ethyl]amino}butan-2-yl]-1-N,1-N-dipropylbenzene-1,3-dicarboxamide::N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({(1S)-1-methyl-2-[(2-methylpropyl)amino]-2-oxoethyl}amino)propyl]-N,N-dipropylbenzene-1,3-dicarboxamide::hydroxyethyl secondary amine (HEA) inhibitor 2

SMILES CCCN(CCC)C(=O)c1cccc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@@H](O)CN[C@@H](C)C(=O)NCC(C)C

InChI Key InChIKey=SRFCEZYLYMKEJM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15791   

TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM15791(N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({(1...)
Affinity DataIC50: 6.80E+4nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed