BDBM1579 11-Cyclopropyl-5,ll-dihydro-4- [ (2-propeny1oxy)methyl]-6H-dipyrido[3,2-b:2 ,3 -e] [ 1,4]diazepin-6-one::2-cyclopropyl-7-[(prop-2-en-1-yloxy)methyl]-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one::Nevirapin 4-substituted deriv. 4b

SMILES C=CCOCc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12

InChI Key InChIKey=WIFLXEJTDWCVIH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1579   

TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1579(11-Cyclopropyl-5,ll-dihydro-4- [ (2-propeny1oxy)me...)
Affinity DataIC50: 1.41E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2004
Entry Details Article
PubMed