BDBM15627 2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrol-2-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline::4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrol-2-yl)(3,4-dihydroisoquinolin-2-(1H)-yl)methane::Pyrrole Carboxamide Analog 5m

SMILES Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)N1CCc2ccccc2C1

InChI Key InChIKey=MWATXBYHLNDFKU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15627   

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM15627(2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrr...)
Affinity DataKi:  510nM ΔG°:  -8.72kcal/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by ERK2 was converted to ATP by pyruvate kinase with the production of pyruvate fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Vertex Pharmaceuticals

LigandPNGBDBM15627(2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrr...)
Affinity DataKi: >4.00E+3nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by ERK2 was converted to ATP by pyruvate kinase with the production of pyruvate fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed