BDBM15564 (3R)-3-amino-1-(1,3-thiazolidin-3-yl)-4-(2,4,5-trifluorophenyl)butan-1-one::CHEMBL363319::DPP-4 ligand 6

SMILES N[C@@H](CC(=O)N1CCSC1)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=INUDFZPOCPXRIM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15564   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM15564(CHEMBL363319 | (3R)-3-amino-1-(1,3-thiazolidin-3-y...)
Affinity DataIC50: 119nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM15564(CHEMBL363319 | (3R)-3-amino-1-(1,3-thiazolidin-3-y...)
Affinity DataIC50: 119nMAssay Description:Inhibitory concentration against Dipeptidyl peptidase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM15564(CHEMBL363319 | (3R)-3-amino-1-(1,3-thiazolidin-3-y...)
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibitory concentration against quiescent cell proline dipeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM15564(CHEMBL363319 | (3R)-3-amino-1-(1,3-thiazolidin-3-y...)
Affinity DataIC50: 119nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM15564(CHEMBL363319 | (3R)-3-amino-1-(1,3-thiazolidin-3-y...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of DPP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed