BDBM15561 (3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[3,4-a]pyrazin-7-yl]butan-1-one::CHEMBL427261::DPP-4 ligand 3

SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(Cl)ccc1F

InChI Key InChIKey=MUMFFVRFHUQYEC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15561   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM15561(CHEMBL427261 | (3R)-3-amino-4-(5-chloro-2-fluoroph...)
Affinity DataIC50: 21nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM15561(CHEMBL427261 | (3R)-3-amino-4-(5-chloro-2-fluoroph...)
Affinity DataIC50: 21nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15561(CHEMBL427261 | (3R)-3-amino-4-(5-chloro-2-fluoroph...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP8 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15561(CHEMBL427261 | (3R)-3-amino-4-(5-chloro-2-fluoroph...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of DPP9 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed