BDBM15558 (3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-[(2-fluorophenyl)methyl]-3-methyl-1,4-diazepan-2-one::7-substituted diazepanone 15i

SMILES C[C@H]1N(CC[C@@H](Cc2ccccc2F)NC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=AOXRPNCMWKRTBA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15558   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM15558((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Affinity DataIC50: 126nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

LigandPNGBDBM15558((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Affinity DataIC50: 8.70E+3nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM15558((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Affinity DataIC50: 1.90E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2007
Entry Details Article
PubMed