BDBM154604 US8999957, Column 162-163, Compound 3

SMILES O=C(N[C@@H]1CCCN(Cc2ccc(cc2)C#N)C1)c1ccc2[nH]nc(-c3ccc4OCCc4c3)c2c1

InChI Key InChIKey=DBDDGASSGLXVMH-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 154604   

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154604(US8999957, Column 162-163, Compound 3)
Affinity DataKd:  82nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154604(US8999957, Column 162-163, Compound 3)
Affinity DataIC50: 1.00E+3nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent