BDBM154589 US8999957, Column 141, Compound 5::US8999957, Table 1, Compound 13

SMILES CC(C)Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1

InChI Key InChIKey=CCSBRKICEAUMTP-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 154589   

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataKd:  1.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataIC50: 443nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataIC50: 275nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataKd:  1.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataIC50: 443nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataIC50: 275nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent