BDBM154486 US9012443, 67

SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccncn1)C(F)(F)F

InChI Key InChIKey=VKSDOTFVEIWXEL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 154486   

LigandPNGBDBM154486(US9012443, 67)
Affinity DataIC50: 80nMAssay Description:293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2015
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM154486(US9012443, 67)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed
LigandPNGBDBM154486(US9012443, 67)
Affinity DataIC50: 730nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed
LigandPNGBDBM154486(US9012443, 67)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed