BDBM153729 N-(3-((4-((5-Methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)oxy)phenyl)propionamide (23)

SMILES CCC(=O)Nc1cccc(Oc2nc(Nc3cc(C)[nH]n3)cc(n2)N2CCN(C)CC2)c1

InChI Key InChIKey=KWKLGZKSENJGLM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 153729   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM153729(N-(3-((4-((5-Methyl-1H-pyrazol-3-yl)amino)-6-(4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM153729(N-(3-((4-((5-Methyl-1H-pyrazol-3-yl)amino)-6-(4-me...)
Affinity DataIC50: 254nMAssay Description:Inhibition of cSrc T338M mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM153729(N-(3-((4-((5-Methyl-1H-pyrazol-3-yl)amino)-6-(4-me...)
Affinity DataIC50: 349nMAssay Description:Inhibition of cSrc T338M/S345C mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM153729(N-(3-((4-((5-Methyl-1H-pyrazol-3-yl)amino)-6-(4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed