BDBM153690 US10507215, Compound 7::US9000015, 7::US9610299, Example 7

SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl

InChI Key InChIKey=SFVKNPJMMRPOCO-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 153690   

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with eserase. Standard MAO reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with eserase. Standard MAO reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 464nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 23nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 464nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 464nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included lumnuogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandPNGBDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included lumnuogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent