BDBM15350 ChemBridge compound no. 5::N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzamide

SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(Cl)c1

InChI Key InChIKey=KOKPPSWBLFTOPX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15350   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15350(N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzam...)
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Human)
University of Texas Southwestern Medical Center

LigandPNGBDBM15350(N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzam...)
Affinity DataIC50: 1.16E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](malaria parasite P. falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15350(N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzam...)
Affinity DataIC50: 500nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [H185A](malaria parasite P. falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15350(N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzam...)
Affinity DataIC50: 1.30E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM15350(N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzam...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article