BDBM153477 US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one (+ enantiomer)::US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one (enantiomer)::US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one (racemic)

SMILES C[Si](C)(C)C1=C2C(CC1=O)CC(O)c1cc3ccccc3nc21

InChI Key InChIKey=OIIOPIIGGQSDJQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 153477   

TargetCyclin-dependent kinase 1(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM153477(US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-t...)
Affinity DataIC50: 650nMAssay Description:The tests are carried out as follows: the enzyme to be assayed was purified, for example by affinity chromatography on agarose beads. The catalytic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM153477(US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-t...)
Affinity DataIC50: 620nMAssay Description:The tests are carried out as follows: the enzyme to be assayed was purified, for example by affinity chromatography on agarose beads. The catalytic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM153477(US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-t...)
Affinity DataIC50: 7.80E+3nMAssay Description:The tests are carried out as follows: the enzyme to be assayed was purified, for example by affinity chromatography on agarose beads. The catalytic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM153477(US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-t...)
Affinity DataIC50: 1.95E+3nMAssay Description:The tests are carried out as follows: the enzyme to be assayed was purified, for example by affinity chromatography on agarose beads. The catalytic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM153477(US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-t...)
Affinity DataIC50: 3.00E+3nMAssay Description:The tests are carried out as follows: the enzyme to be assayed was purified, for example by affinity chromatography on agarose beads. The catalytic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM153477(US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-t...)
Affinity DataIC50: 2.60E+4nMAssay Description:The tests are carried out as follows: the enzyme to be assayed was purified, for example by affinity chromatography on agarose beads. The catalytic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent