BDBM153292 3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-yl)-4,5-dihydro-pyrazole-1-carboxylic acid(4-chloro-phenyl)-amide (1b)

SMILES CN(C)c1ccc(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c2ccccc12

InChI Key InChIKey=SIQTZSSZFTYKGY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 153292   

TargetPhospholipase A2 group V(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153292(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 2.22E+4nMpH: 7.5 T: 2°CAssay Description:Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153292(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 1.87E+3nMpH: 8.0 T: 2°CAssay Description:100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153292(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 9.10E+3nMpH: 8.0 T: 2°CAssay Description:100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
University of Kwazulu Natal

Curated by ChEMBL
LigandPNGBDBM153292(3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...)
Affinity DataIC50: 4.72E+3nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase pre-incubated for 30 mins before L-DOPA substrate addition and measured after 1 min by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed