BDBM153290 3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-(2,3-dimethoxy-naphthalen-1-yl)-4,5-dihydro-pyrazole-1-carbothioic acid amide (5a)

SMILES COc1cc2ccccc2c(C2CC(=NN2C(N)=S)c2ccc3OCCOc3c2)c1OC

InChI Key InChIKey=OXADWCKAEDLENI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 153290   

TargetPhospholipase A2 group V(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153290(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-(2,3-dimet...)
Affinity DataIC50: 1.92E+4nMpH: 7.5 T: 2°CAssay Description:Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153290(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-(2,3-dimet...)
Affinity DataIC50: 3.42E+3nMpH: 8.0 T: 2°CAssay Description:100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz

LigandPNGBDBM153290(3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-(2,3-dimet...)
Affinity DataIC50: 1.78E+4nMpH: 8.0 T: 2°CAssay Description:100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2015
Entry Details Article
PubMed