BDBM153213 US8993756, 12-1

SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(c3)N(C)C(=O)C=C)c12

InChI Key InChIKey=UQOBGKQNECGMLF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153213   

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153213(US8993756, 12-1)
Affinity DataIC50: 0.130nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153213(US8993756, 12-1)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent