BDBM152653 4-(1,3-Dioxoisoindolin-2-yl)-N-(4-ethylphenyl)benzenesulphonamide (16)

SMILES CCc1ccc(NS(=O)(=O)c2ccc(cc2)N2C(=O)c3ccccc3C2=O)cc1

InChI Key InChIKey=VMFMCDJLBJWACL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 152653   

TargetGenome polyprotein(DENV-2)
Birla Institute of Technology

LigandPNGBDBM152653(4-(1,3-Dioxoisoindolin-2-yl)-N-(4-ethylphenyl)benz...)
Affinity DataIC50: 4.82E+4nMpH: 8.5Assay Description:To measure the inhibitory activities of the compounds, the DENV2 NS2B-NS3 protease activities were measured in the presence of the compounds using Bz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2015
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM152653(4-(1,3-Dioxoisoindolin-2-yl)-N-(4-ethylphenyl)benz...)
Affinity DataIC50: 4.82E+4nMAssay Description:Inhibition of DENV2 NS2B-NS3 serine protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM152653(4-(1,3-Dioxoisoindolin-2-yl)-N-(4-ethylphenyl)benz...)
Affinity DataIC50: 4.82E+4nMAssay Description:Inhibition of DENV2 NS2B/NS3 protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed