BDBM152278 US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]isoxazole-3-carboxamide

SMILES Oc1cc(O)c(-c2cc(no2)C(=O)NC2CCN(CC2)C2CCC(F)(F)CC2)c(Oc2ccc(cc2)[N+]([O-])=O)c1

InChI Key InChIKey=IZPJDEVSLUINKO-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152278   

TargetHeat shock protein HSP 90-alpha(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM152278(US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-...)
Affinity DataKd:  0.800nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent