BDBM15218 Isoquinoline-5-sulfonic acid (2S,4S)-(4-(4-chlorobenzyloxy)pyrrolidin-2-yl-methyl)amide::N-{[(2S,4S)-4-[(4-chlorophenyl)methoxy]pyrrolidin-2-yl]methyl}isoquinoline-5-sulfonamide::isoquinoline-5-sulfonamide 50

SMILES Clc1ccc(CO[C@@H]2CN[C@H](CNS(=O)(=O)c3cccc4cnccc34)C2)cc1

InChI Key InChIKey=RLNNFNGBXLTQOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15218   

TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15218(N-{[(2S,4S)-4-[(4-chlorophenyl)methoxy]pyrrolidin-...)
Affinity DataIC50: 480nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15218(N-{[(2S,4S)-4-[(4-chlorophenyl)methoxy]pyrrolidin-...)
Affinity DataIC50: 170nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed