BDBM152160 US8987474, HL2-052-2

SMILES OC(=O)c1ccc2NC(=O)\C(=N/Nc3ccccc3C(O)=O)c2c1

InChI Key InChIKey=CUGFLOKHGAUBLN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 152160   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of South Florida

US Patent
LigandPNGBDBM152160(US8987474, HL2-052-2)
Affinity DataIC50: 3.55E+3nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of South Florida

US Patent
LigandPNGBDBM152160(US8987474, HL2-052-2)
Affinity DataIC50: 800nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of South Florida

US Patent
LigandPNGBDBM152160(US8987474, HL2-052-2)
Affinity DataIC50: 800nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed