BDBM151867 US8987457, 61

SMILES COC(=O)N(C)[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

InChI Key InChIKey=UFRGVTREMFYICD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 151867   

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandPNGBDBM151867(US8987457, 61)
Affinity DataIC50: 0.490nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
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TargetSerine/threonine-protein kinase pim-1(Human)
Novartis

US Patent
LigandPNGBDBM151867(US8987457, 61)
Affinity DataIC50: 0.0300nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM151867(US8987457, 61)
Affinity DataIC50: 1.07nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent