BDBM1517 2-ethyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one::CHEMBL37628::Dipyridodiazepinone deriv. 2

SMILES CCN1c2nccc(C)c2NC(=O)c2cccnc12

InChI Key InChIKey=HDVZWQWXAQRFKJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 1517   

TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 40nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 1.80E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 35nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2004
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 1.50E+3nMAssay Description:Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of tritiated thymidine triphosphate onto a biotinylated rN.dN template pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 35nMAssay Description:Inhibition of HIV-1 reverse transcriptase at 37 degree CentigradeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 1.03E+4nMAssay Description:Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of tritiated thymidine triphosphate onto a biotinylated rA.dT template pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 35nMAssay Description:Inhibition of HIV1 reverse transcriptase derived from HIV patient plasma by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed