BDBM151017 US8987257, 30

SMILES CC(=O)Nc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1

InChI Key InChIKey=IDDGBSMMVIQCFB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151017   

LigandPNGBDBM151017(US8987257, 30)
Affinity DataIC50: 3.01E+3nMpH: 7.5 T: 2°CAssay Description:PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2015
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM151017(US8987257, 30)
Affinity DataIC50: 1.45E+3nMpH: 7.5 T: 2°CAssay Description:IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2015
Entry Details
Go to US Patent