BDBM150758 2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d)::US9271961, 2'-Hydroxyflavone

SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1

InChI Key InChIKey=ZZLQHXCRRMUGQJ-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 150758   

TargetAldo-keto reductase family 1 member C3(Human)
University of Pennsylvania

US Patent
LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataIC50: 300nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C2(Human)
University of Pennsylvania

US Patent
LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataIC50: 4.71E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C1(Human)
University of Pennsylvania

US Patent
LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataIC50: 6.20E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at AR in human LNCAP cells assessed as reduction in DHT-induced cell growth treated for every 2 days for 4 days by hemocytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at AR in human LNCAP cells assessed as reduction in DHT-induced transcriptional activation after 24 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Birla Institute of Technology

LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataKi:  520nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Birla Institute of Technology

LigandPNGBDBM150758(2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) | US9271...)
Affinity DataKi:  5.98E+3nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed