BDBM149887 US8975415, RP168::US9242973, RP168

SMILES CC1(C)Oc2ccc(cc2C2(COC(N)=N2)C11COC1)-c1cnc2[nH]ccc2c1

InChI Key InChIKey=FIXVOAGHXZBUQU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 149887   

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149887(US8975415, RP168 | US9242973, RP168)
Affinity DataIC50: 760nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149887(US8975415, RP168 | US9242973, RP168)
Affinity DataIC50: 760nMAssay Description:Test Example 2: Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149887(US8975415, RP168 | US9242973, RP168)
Affinity DataIC50: 310nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent