BDBM149814 US8975415, RP95

SMILES NC1=NC2(CO1)c1cc(ccc1OC(CCC(F)(F)F)C21CCC1)-c1cncnc1

InChI Key InChIKey=DSTJFWHEXWTHCF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 149814   

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149814(US8975415, RP95)
Affinity DataIC50: 740nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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LigandPNGBDBM149814(US8975415, RP95)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent