BDBM149810 US8975415, RP91::US8975415, RP94::US9242973, RP94

SMILES CCCC1Oc2ccc(cc2C2(COC(N)=N2)C11COC1)-c1cncnc1

InChI Key InChIKey=XGNRRAYBEHJJDH-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 149810   

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 656nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 862nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 656nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 862nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 340nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 380nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 1.00E+4nMAssay Description:Test Example 5: The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were perfor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 1.00E+4nMAssay Description:Test Example 5: The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were perfor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent