BDBM149778 US8975415, RP59::US9242973, RP59
SMILES NC1=NC2(CO1)c1cc(ccc1OCC21CC1)-c1cncc(OCC(F)F)c1
InChI Key InChIKey=WQKBRYBBAYLSSQ-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 149778
Affinity DataIC50: 1.11E+3nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMT: 2°CAssay Description:The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...More data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+3nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
Affinity DataIC50: 76nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblast...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Test Example 5: The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were perfor...More data for this Ligand-Target Pair