BDBM149765 US8975415, RP44::US9242973, RP44

SMILES NC1=NC2(CO1)c1cc(Nc3ncccc3Cl)ccc1OC1(CCC1)C21COC1

InChI Key InChIKey=XYJZKZHKINNLPL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 149765   

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149765(US8975415, RP44 | US9242973, RP44)
Affinity DataIC50: 602nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149765(US8975415, RP44 | US9242973, RP44)
Affinity DataIC50: 602nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149765(US8975415, RP44 | US9242973, RP44)
Affinity DataIC50: 98nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
Go to US Patent