BDBM149705 US8975409, Example 9(3)

SMILES OC(=O)c1ccc(Oc2cc(NC(=O)N3CCC(O)(CC3)c3ccc(F)cc3)cc(Oc3ccc(F)cc3)c2)cc1

InChI Key InChIKey=PZFBUIYFAFMDBM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 149705   

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 3.30nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 430nMAssay Description:Displacement of [33P]S1P from human S1P2 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]S1P from human S1P3 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]S1P from human S1P4 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]S1P from human S1P5 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed