BDBM14962 (S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(3-(methylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide::5-[2-(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-{2-[(3S)-3-(methylamino)piperidin-1-yl]-5-(trifluoromethyl)phenyl}benzamide::alkynylpyrimidine amide 6m

SMILES CN[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F

InChI Key InChIKey=YNUAYENQUDYECY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14962   

TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14962((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14962((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-...)
Affinity DataIC50: 1.01E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14962((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-2-fluoro-...)
Affinity DataIC50: 620nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed