BDBM14958 5-[(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide::5-[2-(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide::alkynylpyrimidine amide 6i

SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F

InChI Key InChIKey=AVHVXKAONMHRSS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14958   

TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14958(5-[(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[2-(...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14958(5-[(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[2-(...)
Affinity DataIC50: 1.10E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14958(5-[(2-aminopyrimidin-5-yl)ethynyl]-2-fluoro-N-[2-(...)
Affinity DataIC50: 210nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed