BDBM14953 3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide::3-[2-(2-aminopyrimidin-5-yl)ethynyl]-4-methyl-N-[2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl]benzamide::alkynylpyrimidine amide 6d

SMILES Cc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F

InChI Key InChIKey=KERAXCVZALMMNG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14953   

TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14953(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(2...)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14953(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(2...)
Affinity DataIC50: 1.00E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
LigandPNGBDBM14953(3-(2-(2-Aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(2...)
Affinity DataIC50: 42nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed