BDBM149434 US10434101, Compound I-36::US11096942, Compound I-36::US8975249, I-36

SMILES FC(F)Oc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1

InChI Key InChIKey=NXBMDDBXMAQAPS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 149434   

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149434(US8975249, I-36 | US10434101, Compound I-36 | US11...)
Affinity DataIC50: 20nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149434(US8975249, I-36 | US10434101, Compound I-36 | US11...)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149434(US8975249, I-36 | US10434101, Compound I-36 | US11...)
Affinity DataIC50: 20nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Celgene Car

US Patent
LigandPNGBDBM149434(US8975249, I-36 | US10434101, Compound I-36 | US11...)
Affinity DataIC50: 1nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149434(US8975249, I-36 | US10434101, Compound I-36 | US11...)
Affinity DataIC50: 20nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Celgene Car

US Patent
LigandPNGBDBM149434(US8975249, I-36 | US10434101, Compound I-36 | US11...)
Affinity DataIC50: 1nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent