BDBM149405 US10434101, Compound I-5::US11096942, Compound I-5::US8975249, I-15::US8975249, I-5

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1

InChI Key InChIKey=SGYVANQNHBGWFO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 149405   

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 20nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 65nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 5.5nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 5.5nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 20nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Celgene Car

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 5.5nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Avilomics Research

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 20nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Celgene Car

US Patent
LigandPNGBDBM149405(US8975249, I-15 | US8975249, I-5 | US10434101, Com...)
Affinity DataIC50: 5.5nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent