BDBM149353 BDBM149355::US8962859, 9B

SMILES NC1=N[C@]2(c3nccn13)c1cc(ccc1Oc1c(F)cc(cc21)N1CCOCC1)-c1cccnc1F

InChI Key InChIKey=OLMKWMUFWPWVRZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 149353   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM149353(US8962859, 9B | BDBM149355)
Affinity DataIC50: 0.700nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM149353(US8962859, 9B | BDBM149355)
Affinity DataIC50: 0.600nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent