BDBM149124 US8962648, 1168::US8962648, 1169

SMILES C[C@@H](CN)c1ccc(cc1)-c1c(O)cc(C)c2[nH]c(=O)c3sccc3c12

InChI Key InChIKey=OETLNMOJNONWOY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 149124   

TargetLymphokine-activated killer T-cell-originated protein kinase(Human)
Oncotherapy Science

US Patent
LigandPNGBDBM149124(US8962648, 1169 | US8962648, 1168)
Affinity DataIC50: 2.60nMpH: 7.4 T: 2°CAssay Description:PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetLymphokine-activated killer T-cell-originated protein kinase(Human)
Oncotherapy Science

US Patent
LigandPNGBDBM149124(US8962648, 1169 | US8962648, 1168)
Affinity DataIC50: 8.90nMpH: 7.4 T: 2°CAssay Description:PBK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetLymphokine-activated killer T-cell-originated protein kinase(Human)
Oncotherapy Science

US Patent
LigandPNGBDBM149124(US8962648, 1169 | US8962648, 1168)
Affinity DataIC50: 11nMAssay Description:Inhibition of human TOPK using MBP as substrate after 2 hrs in presence of [gamma-33P]-ATP by filter-binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM149124(US8962648, 1169 | US8962648, 1168)
Affinity DataIC50: 727nMAssay Description:Inhibition of CDK12/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed