BDBM14847 1-[2-(3-Aminophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]urea::3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB-796 Analog 38::BIRB-796 derivative, 13

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)n(n1)-c1cccc(N)c1

InChI Key InChIKey=CKKYQUBTMVTTRV-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14847   

TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataKd:  0.230nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetPutative glycogen synthase kinase 3 alpha(Corn smut fungus)
Technische UniversitÄT Dortmund

LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische UniversitÄT Dortmund

LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2012
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataIC50: 8nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataKd:  20nMAssay Description:Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische UniversitÄT Dortmund

LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human GSK-3beta using Ser/Thr 6 peptide as substrate preincubated for 60 mins followed by ATP and substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed