BDBM148291 US8962637, 7

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1=O

InChI Key InChIKey=JJHRHADNFSGPGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148291   

TargetTyrosine-protein kinase JAK2(Human)
Debiopharm

US Patent
LigandPNGBDBM148291(US8962637, 7)
Affinity DataIC50: 83nMAssay Description:Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Debiopharm

US Patent
LigandPNGBDBM148291(US8962637, 7)
Affinity DataIC50: 16nMAssay Description:Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent