BDBM14753 (R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline::4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6,7-dimethoxyquinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 16

SMILES COc1ccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)cc1OC

InChI Key InChIKey=LEVUGPXUDZVOIL-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14753   

LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  67nM ΔG°:  -9.68kcal/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  67nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  121nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  121nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  260nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14753(4-[(3R)-3-(3,4-dimethoxyphenoxy)pyrrolidin-1-yl]-6...)
Affinity DataKi:  260nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed