BDBM14746 (R)-6,7-Dimethoxy-4-[3-(4-trifluoromethoxy-phenoxy)-pyrrolidin-1-yl]-quinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 9::6,7-dimethoxy-4-[(3R)-3-[4-(trifluoromethoxy)phenoxy]pyrrolidin-1-yl]quinazoline

SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc(OC(F)(F)F)cc3)c2cc1OC

InChI Key InChIKey=CNUBPTZHDNDDAD-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14746   

LigandPNGBDBM14746(6,7-dimethoxy-4-[(3R)-3-[4-(trifluoromethoxy)pheno...)
Affinity DataKi:  185nM ΔG°:  -9.09kcal/molepH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14746(6,7-dimethoxy-4-[(3R)-3-[4-(trifluoromethoxy)pheno...)
Affinity DataKi:  739nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14746(6,7-dimethoxy-4-[(3R)-3-[4-(trifluoromethoxy)pheno...)
Affinity DataKi:  1.82E+3nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed